SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FOR IMPROVED ORAL BIOAVAILABILITY OF CHLORPROMAZINE: IN VITRO AND IN VIVO EVALUATION

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery.Chlorpromazine, an antipsychotic agent with poor aqueous solubility—with extensive first-pass metabolism—can be a suitable can

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Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?

Animal and clinical studies of gene-environment interactions have helped elucidate the mechanisms involved Modem Router in the pathophysiology of several mental illnesses including anxiety, depression and schizophrenia; and have led to the discovery of improved treatments.The study of neuropeptides and their receptors is a parallel frontier of neur

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A Novel Flood Risk Analysis Framework Based on Earth Observation Data to Retrieve Historical Inundations and Future Scenarios

Global warming is exacerbating flood hazards, making the robustness of flood risk management a critical issue.Without considering future scenarios, flood risk analysis built only on historical knowledge may not adequately address the coming challenges Microphone Accessories posed by climate change.A comprehensive risk analysis framework based on bo

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